Iowa State University

Defining anti-viral activities in Echinacea, Hypericum, and Prunella species

 

Project Leader: Wendy Maury (UI)

 

 

Project Objectives

  • Identification and characterization of constituents present in Hypericum, Prunella, and Echinacea spp. extracts that contain anti-HIV-1 activity.
  • Identification of the mechanism(s) of anti-HIV activities of the extracts, fractions, and the constituents.
  • Determining if botanical bioactive constituents have efficacy against HIV-1 in an ex vivo tonsillar tissue model and an in vivo human CD34+ cell reconstituted Rag2-/-, γ constant chain-/- mice.
  • Characterize the breadth of anti-retroviral activities found in Echinacea, Hypericum, and Prunella spp. by testing the active anti-HIV constituents against other closely and more distantly related retroviruses.

 

 

Office closed during semester break

The Botanical Center's administrative office will be closed December 24 - January 3, in accordance with Iowa State University's semester break recommendation. Normal office hours will resume on Monday, January 4, 2010.

 

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